Ancient human bones reveal the oldest known strain of the plague


062921 jc plague bacteria feat

The oldest known strain of the plague-causing bacteria Yersinia pestis has been found lurking in the bones and teeth of a man buried thousands of years ago in what is now Latvia.

Genetic analysis suggests the Y. pestis strain that infected the man emerged around 7,100 years ago, researchers report online June 29 in Cell Reports. It usurps the previous record-holder, found in a 5,000-year-old Scandinavian mass grave associated with a possible plague epidemic  (SN: 12/6/18). The Latvia man’s bones are also about 5,000 years old, but DNA comparison suggests he contracted a less virulent strain that emerged 1,000 years earlier in Y. pestis history than that found at the Scandinavian site. 

Bacterial DNA also suggest that the ancient plague victim didn’t develop pustules or infect his family. And the strain lacked the gene for swift flea-to-human transmission, which evolved perhaps 3,800 years ago and drove later bubonic plague epidemics, says Ben Krause-Kyora, an archaeologist and biochemist at Kiel University in Germany.

It’s likely this early plague strain passed to humans through isolated encounters, such as from rodent bites, Krause-Kyora and colleagues conclude. The man was carefully buried, and the team didn’t find mass graves or Y. pestis infection in other individuals’ DNA, suggesting people in the area weren’t facing an epidemic (SN: 1/6/21). Without antibiotics, the man probably succumbed to his infection.

Although this Y. pestis is the oldest strain ever found, it ultimately went extinct, being replaced by other, more virulent versions — a common fate in the evolutionary history of both bacteria and viruses. Later Y. pestis strains may have been more contagious, but isolated encounters like this one may help scientists understand the plague’s early history.  “Maybe it’s really single events in the beginning, then more and more severe, before it became really dramatic in medieval times,” Krause-Kyora says.


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